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Opioid Use

The Case Against the Sinclair Method

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The Sinclair Method is a treatment for alcoholism that uses the drug naltrexone to disrupt the pleasurable aspect of drinking. Naltrexone is an opioid antagonist that binds to mu receptors in the brain. The endorphins produced by drinking have nowhere to land and so the pleasure of drinking is more or less extinguished. The Sinclair… Read On »

What Are the Drawbacks of Methadone?

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Methadone has been used to treat opioid use disorder for more than 30 years. It has traditionally been the standard medication for opioid replacement therapy, although buprenorphine has gained in popularity in recent years and now they are used about equally. Many studies have found that methadone significantly improves recovery outcomes for people with opioid… Read On »