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Naltrexone

The Case Against the Sinclair Method

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The Sinclair Method is a treatment for alcoholism that uses the drug naltrexone to disrupt the pleasurable aspect of drinking. Naltrexone is an opioid antagonist that binds to mu receptors in the brain. The endorphins produced by drinking have nowhere to land and so the pleasure of drinking is more or less extinguished. The Sinclair… Read On »